Mandy
The San Francisco 49ers suffered a major blow early in their matchup after star left tackle Trent Williams exited the game with a right hamstring injury, compounding an already disastrous opening sequence for the offense.
Injury Occurs on Opening Defensive Touchdown
The game began in rough fashion for San Francisco. On the first offensive snap, Brock Purdy attempted a pass to Jauan Jennings, but Jaylon Johnson of the Chicago Bears reacted quickly, tipping the ball into the air.
Linebacker T.J. Edwards intercepted the deflection and returned it 34 yards for a touchdown, immediately putting the 49ers in a hole.
Although Williams was not directly involved in the play, he sprinted downfield in an effort to stop the score. During the chase, he suddenly pulled up and grabbed his right hamstring, clearly in discomfort.
Medical Evaluation and Game Status Update
Following the play, Williams went straight to the medical tent along the sideline, remaining there during San Francisco’s next offensive possession.
The team initially listed him as questionable, but the signs were concerning.
When he emerged moments later, Williams removed his gloves and tape—often a clear indication that a return is unlikely.
Before the start of the third quarter, the 49ers officially ruled him out for the remainder of the game.
Austen Pleasants Steps In
With their All-Pro left tackle sidelined, Austen Pleasants was inserted into the lineup.
Prior to this game, Pleasants had logged just 12 offensive snaps all season, making the transition a significant challenge for the offensive line.
Williams’ Season and Career Context
The injury is particularly notable given Williams’ durability in 2025. He had not missed a game this season, despite dealing with an ankle issue that forced him to miss the final seven games of the 2024 season.
Just last week, Williams earned his 12th Pro Bowl selection, the most ever by an offensive tackle, further highlighting how impactful his absence could be for the 49ers offense moving forward.
The loss of Trent Williams represents more than just an injury—it removes a cornerstone of the San Francisco 49ers offensive line.
With limited depth behind him and a young quarterback under center, San Francisco now faces added pressure to adjust quickly.
How the team compensates for Williams’ absence could play a decisive role in upcoming games, especially as the season reaches its most competitive stretch.
FAQs
What injury did Trent Williams suffer?
Trent Williams sustained a right hamstring injury while chasing down a defensive touchdown return.
Did Trent Williams return to the game?
No. Although initially listed as questionable, he was ruled out before the third quarter.
Who replaced Trent Williams in the lineup?
Austen Pleasants replaced Williams at left tackle after having played limited snaps earlier this season.